What is it about?
Articular cartilage reconstruction is aimed at the restoration of damaged joint cartilage. The use of bone cement is one type of methods applicable for this reconstruction. Little is known about the response of the organism to various reconstruction techniques and various biomaterials used for the repair of defects. This paper provides important information about the changes in the concentrations of acute phase proteins and the activity of serum enzymes in pigs within the first 30 days following the repair of experimentally induced articular cartilage defects using two types of biocement powders.
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Why is it important?
The potential use of repair techniques must be evaluated by pre-clinical and clinical studies in animal models, including the assessment of some biochemical parameters. The increased production of acute phase proteins is an important metabolic changes during the inflammatory responses. They may serve as useful biomarkers for the evaluation of postoperative complications, as well as to reflect the extent of surgical trauma.
Perspectives
Because regenerative medicine is an intensively developing area of research, it would be of practical use and important to identify biomarkers that could evaluate the postoperative inflammatory state following the reconstruction and repair of cartilage defects.
DVM Oskar Nagy
University of Veterinary Medicine and Pharmacy in Kosice
Read the Original
This page is a summary of: Changes in the Acute-Phase Protein Concentrations and Activities of Some Enzymes in Pigs Following the Repair of Experimentally Induced Articular Cartilage Defects Using Two Types of Biocement Powder, Animals, November 2019, MDPI AG,
DOI: 10.3390/ani9110931.
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