What is it about?
Histone modification profiles measured by high throughput sequencing do not always have any de fact standard method to treat. This is because we do not know what kind of distribution is proper to describe histone modification distribution over genome.
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Why is it important?
In this study, we propose to make use of tensor decomposition (TD) to process histone modification profiles since TD does not require any assumption about the distribution of histone modification over genome. TD is applied to various histone modification profiles including H3K4me3, H3K27me3, and H3K27ac. It can outperform various the state of art methods including MOSAiCS, DFilter, and HOMER.
Perspectives
Since it is unsupervised method, it should be applied to the wide range of histone modification profile analyses.
Professor Y-h. Taguchi
Chuo Daigaku
Read the Original
This page is a summary of: Optimized Tensor Decomposition and Principal Component Analysis Outperforming State-of-the-Art Methods When Analyzing Histone Modification Chromatin Immunoprecipitation Profiles, Algorithms, August 2023, MDPI AG,
DOI: 10.3390/a16090401.
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