Posterior Midline Activation during Symptom Provocation in Acute Stress Disorder: An fMRI Study

What is it about?

Functional imaging studies of patients with post-traumatic stress disorder showed wide- spread activation of midline cortical areas during symptom provocation, i.e., exposure to trauma-related cues.The present study aimed at investigating neural activation during expo- sure to trauma-related pictures in patients with acute stress disorder (ASD) shortly after the traumatic event. NineteenASD patients and 19 healthy control participantswere presented with individualized pictures of the traumatic event and emotionally neutral control pictures during the acquisition of whole-brain data with a 3-T fMRI scanner. Compared to the control group and to control pictures, ASD patients showed significant activation in midline corti- cal areas in response to trauma-related pictures including precuneus, cuneus, postcentral gyrus, and pre-supplementary motor area. The results suggest that the trauma-related pictures evoke emotionally salient self-referential processing in ASD patients.

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