What is it about?
Water, a simple molecule, can dramatically change the behavior of special liquids called deep eutectic solvents (DES). These solvents are considered "green" alternatives to traditional chemicals. Our research used advanced techniques to examine how water interacts with different types of DES. We discovered that water molecules have a preference for binding to a specific part of the DES. However, the way water affects the DES depends on the exact composition of the solvent.
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Why is it important?
Our findings offer crucial insights into the workings of these environmentally friendly solvents. This knowledge lays the groundwork for groundbreaking advancements in sustainable chemistry and pharmaceutical science, particularly in enhancing the solubility and bioavailability of poorly water-soluble drugs.
Perspectives
This research is an exciting first step in our API-DES project, aiming at improving active pharmaceutical ingredients (API) solubility with deep eutectic solvents (DES). Understanding how water interacts with these solvents is fundamental to our goal of improving drug solubility. By employing the unique capabilities of inelastic neutron spectroscopy, we've uncovered crucial insights that will guide our future research. We're eager to share the next phase of our work as we delve deeper into the complex interactions between APIs, water, and DES.
Prof. Paulo Ribeiro-Claro
Universidade de Aveiro
Read the Original
This page is a summary of: Water in Deep Eutectic Solvents: New Insights From Inelastic Neutron Scattering Spectroscopy, Frontiers in Physics, February 2022, Frontiers,
DOI: 10.3389/fphy.2022.834571.
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