What is it about?
In the study, we investigated the anti-cancer effect of clinopodiside A and the underlying mechanisms using T24 bladder cancer cells as an experimental model. We found that the compound inhibited the growth of bladder cancer cells in vitro and in vivo in a concentration- and dose-dependent manner, respectively, which showed a combinational effect when used together with cisplatin.
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Why is it important?
In the bladder cancer cells, clinopodiside A caused autophagy, which was independently mediated by the signaling of BLK and RasGRP2. Inhibition of the autophagy by chemical inhibitor 3-methyladenine or by the inhibition of the signaling molecules attenuated the cytotoxicity of clinopodiside A.
Perspectives
Clinopodiside A is a promising investigational drug for the treatment of cancer, at least blabber, which can be used alone or in combination with clinical drug(s).
Professor Aida Ibrahim El makawy
Read the Original
This page is a summary of: The novel antitumor compound clinopodiside A induces cytotoxicity via autophagy mediated by the signaling of BLK and RasGRP2 in T24 bladder cancer cells, Frontiers in Pharmacology, September 2022, Frontiers,
DOI: 10.3389/fphar.2022.982860.
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