Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for Glioblastoma Treatment

What is it about?

Here, we propose a possible strategy for treating Glioblastoma (GBM), the most frequent and aggressive primary tumor of the brain. We exploit the covalent linkage of drugs to ROS-responsive molecules for a selective drug release in GBM and report our results from in vitro experiments using different cells lines treated with innovative and tailored ROS-responsive prodrugs.

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