The frequency of NUDT15 rs116855232 and its impact on mercaptopurine-induced toxicity in Syrian children with acute lymphoblastic leukemia

What is it about?

This study assessed the association of the NUDT15 (c.415C>T; rs116855232) polymorphism with 6MP dose intolerance in Syrian patients with childhood ALL. We have shown that the evaluated SNP is not common in this population and that the 6MP dose intensity was considerably lower in the TT genotype than in the CT and CC genotypes.

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Why is it important?

Studying the frequency of polymorphisms of the NUDT15 not only helps in the dosing of 6MP in patients with ALL, but it may also give an idea of its frequency in patients with inflammatory bowel diseases (IBD) and rheumatoid arthritis to avoid thiopurine induced toxicity. However, Studies on patients with the other diseases are needed to determine the exact frequency and impact.