Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder

What is it about?

. In 2014, we were the first group to report a new model for autism based on dietary manipulation (zinc deficiency) of pregnant mice (Grabrucker et al., 2014, Brain). In this study, we provide a mechanistic explanation for the behaviour from a synaptic dysfunction that leads to altered connectivity, which results in abnormal lateralisation of the brain, up to the behavioural features arising from this.

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