What is it about?
We demonstrate that in vivo the full (terminal) differentiation of hippocampus neurons in adult mice requires Tis21, or NeuroD2, or the silencing of Id3. This is the first demonstration that Id3 and NeuoD2 play a role in terminal differentiation of the hippocampus neurons.
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Why is it important?
Possible implication and use of Tis21, Id3 or NeuroD2 in neurodegnerative diseases, since in ALzheimer's disease, for instance, there are defects of terminal differentiation in the neurons of the dentate gyrus of the hippocampus.
Perspectives
Possible role in neurodegenerative disease for Tis21, Id3 or NeuroD2, since in Alzheimer's disease, for instance, there are defects of differentiation of dentate gyrus neurons.
Dr Felice Tirone
National Research Council Italy
Read the Original
This page is a summary of: Terminal Differentiation of Adult Hippocampal Progenitor Cells Is a Step Functionally Dissociable from Proliferation and Is Controlled by Tis21, Id3 and NeuroD2, Frontiers in Cellular Neuroscience, July 2017, Frontiers,
DOI: 10.3389/fncel.2017.00186.
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