What is it about?
The appearance of multi-resistant strains has contributed to reintroducing polymyxin as the last-line therapy. Although polymyxin resistance is based on bacterial envelope changes, other resistance mechanisms are being reported. We explored whether OMVs produced by the hypervesiculating strains Salmonella Typhi ΔrfaE (LPS synthesis), ΔtolR (bacterial envelope) and ΔdegS (misfolded proteins and σE activation) exhibit protective properties against polymyxin B. We found that the OMVs extracted from S. Typhi ΔtolR and ΔdegS protect S. Typhi WT from polymyxin B in a concentration-depending manner.
Featured Image
Why is it important?
This phenomenon might be considered the source for the emergence of polymyxin resistance in an entire bacterial community. This work showed that mutants in genes related to OMVs biogenesis can release vesicles with improved abilities to protect bacteria against membrane-active agents such as polymyxin B.
Perspectives
Since OMVs can also protect against other agents such as antimicrobial peptides, which can be produced by the innate immune system (Urashima et al., 2017), the possible role of vesicles in bacterial pathogenesis as protective agents is progressively gaining attention.
Dr Alexander Carreño
UNAB
Read the Original
This page is a summary of: “One for All”: Functional Transfer of OMV-Mediated Polymyxin B Resistance From Salmonella enterica sv. Typhi ΔtolR and ΔdegS to Susceptible Bacteria, Frontiers in Microbiology, May 2021, Frontiers,
DOI: 10.3389/fmicb.2021.672467.
You can read the full text:
Contributors
The following have contributed to this page
