Cell Wall associated virulence factors that play a critical role in aging in Cryptococcus neoformans

What is it about?

Replicative aging in pathogenic fungi leads to development of resilient older generation cells that persists in a infecting population causing recurrent infections. In this paper, the role of cell wall associated virulence factors were studied that contributed to increased virulence in older generation of cells.

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Why is it important?

Older generation of cells persists in an infecting population and hence the mechanism of resilence in the old cell population needs to be characterized for better understanding cell aging and aging related resilience to drugs