What is it about?
In drug discovery, we often find that compounds do not have a singular effect or target; indeed, effects can be multifaceted. This withstanding, our current research does provide strong evidence that BIP inhibits known virulence genes. Future work is needed to determine the specific mechanisms that convey the anti-virulence effect.
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Why is it important?
The finding suggests that exposure of MW2 cells to BIP results in down-regulation of major virulence factors, such as agrA, spa, codY. Moreover, the MW2 cells become more vulnerable to phagocytosis-mediated bacterial killing and, in turn, less virulent in a model host. Based on our findings, we conclude that BIP is an anti-virulence candidate compound that deserves further study.
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This page is a summary of: The Anti-virulence Efficacy of 4-(1,3-Dimethyl-2,3-Dihydro-1H-Benzimidazol-2-yl)Phenol Against Methicillin-Resistant Staphylococcus aureus, Frontiers in Microbiology, July 2019, Frontiers,
DOI: 10.3389/fmicb.2019.01557.
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