What is it about?
We worked on the mode of action of antibiofilm peptides in a mouse model that would further help to understand how this alternative treatment could work in the future.
Featured Image
Why is it important?
Alternatives to antimicrobials barely enter the clinics. One major issue is the problematic that experiments performed under laboratory conditions are simply not transferable to host conditions. Plain language: they just fail to perform similarly - so any kind of in-lab-experiment is useless unless otherwise proved in a model system. We used various mutants to show different susceptibility to our peptides in a cutaneous infection model that allowed to transfer conclusion made under artificial laboratory conditions to a relevant model system.
Perspectives
Over the past years, my personal experience showed that in vitro performed experiments simply were not able to translate to in vivo conditions. I believe that our data provides significant conclusions that antibiofilm peptides work in an abscess model of high bacterial-density infection by targeting the stringent stress response; a pathway very common among bacterial organisms.
Dr Daniel Pletzer
University of Otago
Read the Original
This page is a summary of: Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model, Frontiers in Microbiology, September 2017, Frontiers,
DOI: 10.3389/fmicb.2017.01867.
You can read the full text:
Contributors
The following have contributed to this page
