Immunomodulatory Potential of Human Adipose Mesenchymal Stem Cells Derived Exosomes

What is it about?

Exosomes from MSCs are thought to have similar functions to MSCs such as repairing and regeneration of damaged tissue, but little is known about the immunomodulatory effect of these vesicles.

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Why is it important?

The phenotypic characterization of cytotoxic and helper T cells together with functional assays demonstrated that exo-hASCs exerted an inhibitory effect in the differentiation and activation of T cells as well as a reduced T cell proliferation and IFN-γ release on in vitro stimulated cells. In summary, here we demonstrate that MSCs-derived exosomes are a cell-derived product that could be considered as a therapeutic agent for the treatment of inflammation-related diseases.