What is it about?
Natural Killer (NK) cells may play an important role in the immune response against hematological malignancies as demonstrated in the setting of stem cell transplantation. However, abnormal NK cytolytic function is observed in several hematological malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Several mechanisms are involved in this abnormal function including a decreased expression of NKp46, NKp30 and DNAM-1 activating receptors.
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Why is it important?
Our in vitro model supports the role of IL-15 regulating NK cell cytotoxic function and improving NK cell capacity to induce DC maturation. Further studies are required for integrating IL-15 activated NK cells into NK cell-based immunotherapeutic strategies.
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This page is a summary of: In vitro culture with IL-15 increases NK cell degranulation and enhances NK cell-mediated dendritic cell maturation, Frontiers in Immunology, January 2013, Frontiers,
DOI: 10.3389/conf.fimmu.2013.02.00775.
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