Immunity to the gonococcus

What is it about?

This e-book is a collection of 12 articles from leading contributors to the field, affording a comprehensive overview of current understanding and suggesting future pathways of investigation that should lead to actionable understanding of the immuno-pathogenesis of gonococcal infection, as well as facilitate novel approaches to therapeutic treatment and the development of a prophylactic vaccine. The articles fall broadly into two connected threads: human immune responses to gonococcal infection; and gonococcal vaccine development.

Featured Image

Why is it important?

The need for this understanding is highlighted by the ongoing emergence of resistance in N. gonorrhoeae to all currently available antibiotics, which threatens to render gonorrhea untreatable, as well as the unacceptably high prevalence of gonorrhea. Global incidence is now estimated at 87 million new infections every year, with the heaviest burden of reproductive tract morbidity falling on women, especially in low- and middle-income countries and underserved populations.