Uncovering Potential Antidiabetic and Antihypertension Peptides from Housefly Larvae Proteins

What is it about?

This study sought to uncover peptides released from housefly larvae proteins (HFL) when they are digested in the human gastrointestinal tract. Using a computational approach, 783 peptides were found, 243 of which had 13 different bioactivities like anti-dipeptidyl peptidase IV (anti-DPP-IV) and anti-angiotensin converting enzyme (anti ACE). After further screening, five non toxic and non allergenic dipeptide molecules were discovered that could interact with DPP IV or ACE enzymes through hydrophobic interactions, possibly acting as inhibitors for these two enzymes. This research suggests that HFL proteins could be used in antidiabetic and antihypertension functional food and therapy products to help people manage their conditions.

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Photo by Emma Leigh on Unsplash

Photo by Emma Leigh on Unsplash

Why is it important?

This research is significant as it offers a potential solution to the increasing prevalence of diabetes and hypertension. Through identifying peptides from HFL proteins, this study has identified molecules that could be used in functional food or therapy products for treating these conditions. These dipeptide molecules are non-toxic, non-allergenic and have high gastrointestinal absorption rates, making them excellent candidates for use in such treatments.