What is it about?
Safinamide has a double-mechanism of action, dopaminergic and non-dopaminergic. With this innovative activity, safinamide is effective not only on motor symptoms of PD, but even on some non-motor symptoms. In this paper we showed the long-term efficacy of safinamide on mood disorders, present in 30-40% of the Parkinsonian patients.
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Why is it important?
To confirm the efficacy of safinamide in modulating the abnormal glutamate release and its positive effects on mood and depression in PD patients.
Perspectives
This is the first publication on the safinamide efficacy on management of mood disturbances. Other double-blind, prospective studies are warranted to confirmt hese preliminary results.
Dr Carlo Cattaneo
Zambon SpA
Read the Original
This page is a summary of: Long-Term Effects of Safinamide on Mood Fluctuations in Parkinson’s Disease, Journal of Parkinson s Disease, November 2017, IOS Press,
DOI: 10.3233/jpd-171143.
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