What is it about?
We tested the ability of different tau PET thresholds, in different areas of the brain, to predict cognitive decline over time. We also tested the performance of these same thresholds to predict cognitive decline in the proposed new multi-level staging for Alzheimer's disease.
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Photo by National Cancer Institute on Unsplash
Why is it important?
Tau accumulates in Alzheimer's disease and is associated with short term clinical progression and faster rates of cognitive decline. We need to determine the best threshold of tau accumulation to predict cognitive decline.
Perspectives
As the medical community works to create treatments for Alzheimer's disease, it's important, as researchers, to continue working to understand what drives the symptoms that we see in patients. This is a continuation of the work that my group has been doing to evaluate what role tau plays and how we can use measures of tau to tell us how AD will progress.
Alexandra Gogola
University of Pittsburgh
Read the Original
This page is a summary of: Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies, Journal of Alzheimer s Disease, August 2024, IOS Press,
DOI: 10.3233/jad-240543.
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