What is it about?
Magnetite nanocrystals co-exist in amyloid plaque, resulting in redox toxicity. We use proton transmission beam to induce stimulated emission of electrons from magnetite to remove plaque and toxic magnetite. We have achieved therapeutic effects of innovative proton stimulation on Alzheimer disease mouse by reduction of Amyloid plaque and neuroinflammation, resulting in memory improvement.
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Why is it important?
Proton stimulation is non-invasive and non-pharmacological treatment of Alzheimer disease safely. It opens new window of therapeutic innovation by simple low-dose proton transmission beam without damaging normal brain tissue. It can reduce neuroinflammation and followed by blocking tau pathology, and restoration of neurogenesis consequently.
Perspectives
Iron accumulation and co-existence of metal-oxide nanoparticles with abnormal protein aggregation are a common phenomena in neurodegenerative diseases. I hope this article makes people have idea and interest for the application of proton stimulation to other neurodegenerative diseases like Parkinson disease or ALS.
Professor Jong-Ki Kim
Catholic University of Daegu
Read the Original
This page is a summary of: Proton Stimulation Targeting Plaque Magnetite Reduces Amyloid-β Plaque and Iron Redox Toxicity and Improves Memory in an Alzheimer’s Disease Mouse Model, Journal of Alzheimer’s Disease, October 2021, IOS Press,
DOI: 10.3233/jad-210739.
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