What is it about?

As we age many of our brain function, including memory, get progressively. This study found that decline in the physical fitness and the gradual stiffening of the central arteries of the body (mainly the aorta) that tend to occur as we get older explain the variation in memory, specifically spatial working memory, that is usually associated with general ageing. Surprisingly, however, there was no direct relationship between fitness and the health of the central arteries - at least at the specific time point.

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Why is it important?

Cognitive decline, particularly in the later stages of life, may eventually result in distress and difficulties in daily life. Exercise and fitness have been shown to assist in reducing the rate of this decline, and even in reducing the risk of developing dementias, such as Alzheimer's disease. Our findings support this previous research with respect to fitness. Additionally, in conjunction with the health of the central arteries, appears to explain all of the variation in working memory usually associated with 'getting older'. These findings add weight and evidence to the potential use of exercise and health monitoring as a preventative strategy to reduce the loss of brain functions, and even decreasing the risk of developing dementia. This is very important, particularly given the current lack of effective pharmacological interventions or treatments.

Perspectives

Exercise and fitness have positive effects on the preservation of cognitive functionality and reduction of dementia risk. However, it is currently unclear the mechanism(s) by which this occurs. Research into this area, such as this, helps to discover the biological processes by which exercise manages to affect the function of the brain. This type of research has the potential to point to specific biomarkers associated with exercise/fitness and preservation of cognitive function - which in turn could lead to the development and assessments of more effective exercise intervention strategies

Greg Kennedy
Swinburne University of Technology

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This page is a summary of: Physical Fitness and Aortic Stiffness Explain the Reduced Cognitive Performance Associated with Increasing Age in Older People, Journal of Alzheimer’s Disease, May 2018, IOS Press,
DOI: 10.3233/jad-171107.
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