What is it about?
The paper produces a theoretical blood protein binding model to explain the poor performance of an anti-cancer drug seen in pre-clinical and clinical trials. The model is tested against experimental data.
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Why is it important?
This work is important in linking basic research to pre-clinical and clinical trials. It explains flavopiridols poor performance in clinical trials. The model developed could potentially be used for any drug-blood protein binding systems.
Perspectives
Although this theoretical model is the start, I believe it could be important in explaining drug-blood protein binding work.
Daniel Myatt
Read the Original
This page is a summary of: The correlation of plasma proteins binding capacity and flavopiridol cellular and clinical trial studies, Biomedical Spectroscopy and Imaging, June 2017, IOS Press,
DOI: 10.3233/bsi-170165.
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