What is it about?
The adverse outcome pathway (AOP) concept was first proposed as a tool for chemical hazard assessment facilitating the regulatory decision-making in toxicology and was more recently recommended during the BioMed21 workshops as a tool for the characterization of crucial endpoints in the human disease development. This AOP framework represents mechanistically based approaches using existing data, more realistic and relevant to human biological systems. In principle, AOPs are described by molecular initiating events (MIEs) which induce key events (KEs) leading to adverse outcomes (AOs). In addition to the individual AOPs, the network of AOPs has been also suggested to beneficially support the understanding and prediction of adverse effects in risk assessment. The AOP-based networks can capture the complexity of biological systems described by different AOPs, in which multiple AOs diverge from a single MIE or multiple MIEs trigger a cascade of KEs that converge to a single AO.
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Why is it important?
The application of AOP network as a tool for better understanding the complexity of biological systems and for predicting the adverse effects.
Perspectives
A proposed AOP network for the tau-driven AOP may help to contribute into unravelling of the interactions among existing mechanistic data linked to memory loss as an early phase of sAD pathology.
Dr. Erwin L J Roggen
ToxGenSolutions BV
Read the Original
This page is a summary of: Building a Network of Adverse Outcome Pathways (AOPs) Incorporating the Tau-Driven AOP Toward Memory Loss (AOP429), Journal of Alzheimer s Disease Reports, June 2022, IOS Press,
DOI: 10.3233/adr-220015.
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