What is it about?
The COVID-19 pandemic caused by SARS-CoV-2 is influenced by genetic and epigenetic factors, including miR-155, which affects immune cell and virus functions and laboratory biomarkers. This study evaluates miR-155's role as a biomarker for SARS-CoV-2 detection and monitoring, examining its significance in identifying infection in both vaccinated and unvaccinated individuals using ROC curve analysis. Among the miRNAs, miRNA-155 (miR-155) has been thoroughly examined in individuals with SARS-CoV-2 that is either severe or mild. According to reports, people infected with SARS-CoV-2 may be instructed to trigger a cytokine storm or strong pro-inflammatory reactions. CRP and miR-155 exhibited a strong and positive correlation, Consequently, the molecules have the capacity to control the expression of the viral and immune system proteins inside the host cells. Based on these findings, MiR-155 has been shown to have a major role in the pathophysiology and severity of SARS-CoV-2, and it may be used as a clinical biomarker for early infection severity and detections
Featured Image
Photo by Viktor Forgacs™️ on Unsplash
Why is it important?
Our results are shown. Research on miR-155 and its connection to the SARS-CoV-2 virus is essential for gaining insights into the underlying mechanisms of SARS-CoV-2 pathogenesis. Investigating the role of miR-155 as a potential biomarker could provide valuable information for developing effective diagnostic and therapeutic strategies for SARS-CoV-2.
Perspectives
It was a pleasure to write this article because it includes co-authors with whom I have had a long-standing collaboration. This article also links groups of Covid-19 Vaccination and non-vaccination ,patients with mild to severe infection and their relationship to epigenetic factors. It also suggests using these factors as a diagnostic tool or potentially as a therapeutic tool due to their importance in regulating gene expression and stopping virus transcption.Forthermor ,miRNAs may mediate both activation and inhibition of transcription of a target gene.Also,with regard to viral infections, miR-155 may be a viable therapeutic target .
Dr. Halah Jabbar Kadhim
University of Baghdad
Read the Original
This page is a summary of: Expression level of non-coding (MiR-155) gene as biomarker for severity of coronaviruses infection among vaccinated and non-vaccinated Iraqi patients, Human Antibodies, April 2024, IOS Press,
DOI: 10.3233/hab-240008.
You can read the full text:
Contributors
The following have contributed to this page
