Azoospermia Factor (AZF) and Inhibin B Level in Non-Obstructive Azoospermia

What is it about?

The Role of Micro-deletion of the azoospermia factor (AZF) region located on long arm of the Y-chromosome (Yq11)- which is considered as the commonest observed genetic cause among infertile males- & Inhibin-B in evaluating azoo-spermic males.

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Why is it important?

Non-obstructive Azoo-spermia (NOA) is the most severe form of male infertility, involving about 1% of male population and 10% of infertile males. in one-third of azoospermic males, there is a noticeable genetic abnormality resulting in defective spermatogenesis. Diagnosis of genetic causes of azoospermia often depends on identification of structural and numerical chromosomal anomalies, Y-chromosome micro-deletions, as well as cystic fibrosis transmembrane conductance regulator. Moreover, inhibin-B level is considered as an index of Sertoli cell numbers & integrity mutations.