What is it about?
We demonstrate that gut microbiota remodeled by the extract of millet bran protein (EMBP) alleviates HFD-induced MetS in mice by improving gut barrier function. Based on the crosstalk between microbe and host viewpoint, we reveal the mechanism, which EMBP effectively relieves MetS via the gut microbiotaGABA-nuclear erythroid 2-related factor 2 (NRF2)/Srxn1-gut barrier axis. Therefore, our data suggest that the metabolite GABA-derived from gut microbes (especially B. acidifaciens) may contribute to the prevention and therapy of MetS, demonstrating the crosstalk between dietary millet bran protein and gut microbiota drives the improvement of the novel dietary guidelines for therapy of MetS.
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Why is it important?
Gut microbiome play an important role in the prevention and treatment of MetS. The extract of millet bran protein (EMBP) can inhibit host metabolic diseases by remodeling intestinal microbiome, and can be used as the next generation of dietary supplements to intervene in metabolic diseases.
Perspectives
This study provides novel pharmacological strategies for intervention of whole grain dietary nutritional molecules on MetS and contributes to the development of EMBP as the next generation of nutritional and pharmacological agent for MetS prevention.
ruopeng yin
Read the Original
This page is a summary of: Gut microbiota remodeling drived by dietary millet protein prevents the metabolic syndrome, Food Science and Human Wellness, July 2024, Tsinghua University Press,
DOI: 10.26599/fshw.2022.9250165.
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