What is it about?
This study aimed to investigate the RAS gene polymorphisms. The genetic study included an extraction of genomic DNA and PCR technique to detect the role ofACE2 gene (rs 2285666) in the incidence of COVID-19.
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Why is it important?
The results showed a statistically significant association between ACE2 (rs2285666) with COVID. The genotype wild-type homozygous (GG) was 65.67% in the CoV-19 group and 20% in the control group while the mutant homozygous (AA) was 11.9% in the CoV-19 group and 63.3% in the control. Furthermore, the wild-type homozygous (GG) and allele (G) may be considered a risk factor (etiological fraction E. F) for COVID-19 in Iraqi patients, whereas the mutant homozygous (AA) and allele (A) may be considered a protective factor (preventive fraction). In the present study, it was observed that the wild-type genotype and the G allele were significantly associated with the prevalence and risk of SARS-CoV-2 infection Keywords:
Perspectives
The results confirm the role of SNP rs2285666 variation of ACE2 receptor in susceptibility to COVID-19 in Iraqi patients. This suggested that the ACE2gene on purpose as a candidate genetic locus for the incidence of COVID-19.
Assistant Professor Yasir Mufeed Abdulateef
University of Anbar
Read the Original
This page is a summary of: Genetic Association of Angiotensin-converting enzyme 2 ACE-2 (rs2285666) Polymorphism with the Susceptibility of COVID-19 Disease in Iraqi Patients, February 2023, University of Benin,
DOI: 10.26538/tjnpr/v7i2.7.
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