Diabetes in Diarrhea-Associated Hemolytic Uremic Syndrome: A Systematic Review and Meta-Analysis

What is it about?

The study aimed to quantify the incidence of diabetes during the acute phase of diarrhea-associated hemolytic uremic syndrome (D+HUS) and to identify features associated with its development. A systematic review and meta-analysis of articles assessing diabetes during D+HUS were conducted. Twenty-one studies from six countries were included, with the incidence of diabetes during the acute phase of D+HUS ranging from 0 to 15%, with a pooled incidence of 3.2% (95% CI 1.3-5.1, significant heterogeneity among studies, P = 0.007). Children who developed diabetes were more likely to have severe disease and had higher mortality than those without diabetes. Recurrence of diabetes was possible up to 60 months after initial recovery. The study concludes that children with D+HUS should be observed for diabetes during their acute illness, and long-term screening of D+HUS survivors for diabetes should be considered.

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Why is it important?

This research is important as it sheds light on the incidence of diabetes during acute phase of diarrhea-associated hemolytic uremic syndrome (D+HUS) and identifies features associated with its development. It is important to identify the incidence and characteristics of children who develop diabetes during D+HUS to better understand the disease and provide appropriate treatment. Key Takeaways: 1. The incidence of diabetes during the acute phase of D+HUS in children ranges from 0 to 15% with a pooled incidence estimated at 3.2% (95% CI 1.3-5.1). 2. The development of diabetes was associated with severe disease, marked by central nervous system symptoms, the need for acute dialysis, and mortality. 3. Early aggressive treatment of hyperglycemia will not only prevent ketoacidosis but may improve acute outcomes, as has been shown in other critically ill patients. 4. Long-term screening of D+HUS survivors for diabetes should be considered.