What is it about?
Diabetes increases dementia risk 2-3 fold. We found that people with diabetes on metformin had slower cognitive decline compared to those not and 80% lower dementia rates.
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Why is it important?
Metformin may have neuroprotective effects in older people with diabetes. What are the mechanisms for this neuroprotection?
Perspectives
The findings suggest that older people with type 2 diabetes derive neurocognitive benefit from metformin.
Katherine Samaras
St Vincent's Hospital Sydney
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This page is a summary of: Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study, Diabetes Care, September 2020, American Diabetes Association,
DOI: 10.2337/dc20-0892.
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