What is it about?
We assessed the association of derivatives of reactive oxygen metabolites (d-ROMs) levels and total thiol levels (TTL) with incident major cardiovascular events (MCE), cancer incidence and all-cause mortality in 2,125 type 2 diabetes mellitus (T2DM) patients from two German cohort studies. Both oxidative stress biomarkers and the d-ROMs-to-TTL ratio were statistically significantly associated with all-cause mortality in the individual cohorts and in meta-analyses of both cohorts. In addition, the d-ROMs-to-TTL ratio was significantly associated with incident MCE but this association did not persist after adjustment for diseases and CRP. No association was observed between oxidative stress biomarkers and total cancer incidence. These results suggest that an imbalanced redox system is on the causal chain from morbidity to mortality in T2DM patients.
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Why is it important?
To the best of our knowledge, there was no previous study that assessed the predictive values of d-ROMs levels or TTL for MCE, cancer or all-cause mortality in patients with T2DM.
Perspectives
Pharmacological treatments for high oxidative stress among T2DM patients are not available so far and classical antioxidants like vitamin E or C did not reduce mortality in meta-analyses of previous studies. While the search for effective treatments for high oxidative stress should go on, our study can recommend using d-ROMs and TTL measurements as endpoints in clinical trials that evaluate interventions against high oxidative stress in T2DM patients. Furthermore, they may be helpful for personalized medicine by identifying diabetes patients with a particularly high risk of pre-mature death.
Ben Schöttker
German Cancer Research Center
Read the Original
This page is a summary of: Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies, Diabetes Care, June 2019, American Diabetes Association,
DOI: 10.2337/dc19-0292.
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