High-Intensity Training for Glucose and Acid-Base Regulation During Exercise in Type 1 Diabetes

What is it about?

The study examined the effects of high-intensity exercise (HIE) training on glycemia and acid-base regulation during intermittent HIE in type 1 diabetes. HIE training did not alter A1C in type 1 diabetic subjects, and resting plasma glucose was higher in type 1 diabetic subjects than in control subjects. Exercise induced a sustained rise in plasma glucose from rest, and insulin did not differ between groups at rest or after training. Plasma strong ion difference fell after exercise, with no group differences. After training, SID was higher in both groups, and bicarbonate fell less. The dramatic rises in plasma [H+] and lactate during HIE were markedly attenuated after training, with no group differences. Acid-base status during HIE depends primarily on the SID and PCO2.

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Why is it important?

This research is important as it investigates the effects of high-intensity exercise (HIE) training on glycemia and acid-base regulation during intermittent HIE in type 1 diabetes. Understanding these effects can provide valuable insights for developing patient guidelines and improving the management of type 1 diabetes. Key Takeaways: 1. HIE training may reduce the characteristic post-exercise rise in plasma glucose and reduce acid-base balance perturbations in type 1 diabetes. 2. Intermittent HIE may reduce hyperglycemia in type 1 diabetes, while sustained hyperglycemia is induced during continuous HIE. 3. Acid-base disturbances during exercise may be heightened in type 1 diabetes, and the effects of HIE training on glycemia and acid-base balance during intermittent HIE in type 1 diabetes are unknown. 4. The study found that HIE training did not alter A1C in type 1 diabetic subjects, and the rise in plasma glucose during exercise was attenuated after training. 5. Plasma strong ion difference (SID) was calculated and found to be greater in type 1 diabetic subjects than control subjects across all times and both days, but was within the normal range. 6. After training, the dramatic rises in plasma [H+] and lactate during HIE were markedly attenuated, and bicarbonate fell less, with no group differences.