What is it about?
Chronic diabetic wounds do not heal easily due to the lack of vascularization. Stem cell transplantation using endothelial progenitor cells failed because of the very low and compromised status of these in diabetic patients. Thus, our study identified a novel way of using a unique transcription factor-mediated reprogramming of adult mesenchymal stromal cells into endothelial cells. The allogeneic transplantation of these TWIST1-reprogrammed endothelial cells potentiated neovascularization at the wound site and enhanced skin tissue regeneration in both type 1 and type 2 diabetic wounds.
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Why is it important?
This study is of utmost importance clinically due to the lack healing of diabetic wounds often leads to amputation and human sufferings. This proof-of-concept pre-clinical study shows the hope of translational efficacy in the near future.
Perspectives
Use of unique transcription factor that promotes transdifferentiation of adult mesenchymal stromal cells into endothelial cells is the novel method of reprogramming the cell fate and the proof-of-concept pre-clinical diabetic model supports the translational efficacy of the study.
Dr. Amitava Das
CSIR-Indian Institute of Chemical Technology
Read the Original
This page is a summary of: TWIST1-Reprogrammed Endothelial Cell Transplantation Potentiates Neovascularization-Mediated Diabetic Wound Tissue Regeneration, Diabetes, March 2020, American Diabetes Association,
DOI: 10.2337/db20-0138.
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