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The development of IR in obese subjects is associated with decline in insulin clearance (MCRI) that represents a compensatory response to maintain normal glucose tolerance but is impaired in T2DM individuals. During OGTT the MCRI suppressed within 15-30 minutes similarly in NGT and IGT subjects and remained suppressed. In contrast, in T2DM MCRI suppression is minimal.
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This page is a summary of: Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance, Diabetes, October 2020, American Diabetes Association,
DOI: 10.2337/db19-1152.
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