What is it about?
About one out of two diabetic patients develop diabetic neuropathy, of these 20% experience neuropathic pain leading to individual, social and health-economic burden. Risk factors for nauropathic pain are largely unknown, however DNA methylation was recently associated with neuropathies and degeneration of nerve fibers.
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Why is it important?
We discovered distinct DNA methylation patterns in type 2 diabetes patients with painful and painless neuropathy. Moreover, we identified genes that could be potential therapeutic targets for neuropathic pain, such as GCH1, MYT1L and MED16, which are interesting to be further investigated.
Perspectives
Identified genes can serve as reference for future studies on painful diabetic neuropathy and pain in general. Our findings provide epigenetic signatures that could be useful to better profile patients at risk of developing neuropathic pain and also lead to the development of potential new avenues of treatment.
katarzyna malgorzata kwiatkowska
University of Bologna
Read the Original
This page is a summary of: High-resolution whole-genome DNA methylation revealed unique signatures of painful diabetic neuropathy, Diabetes, January 2025, American Diabetes Association,
DOI: 10.2337/db24-0930.
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