What is it about?
An azoimine compound, 5-chloro-2-(phenylazo)pyridine (Clazpy), reacted with Ni(II) and Zn(II) sulphate salts and formed divalent metal complexes with a general formula of [M(Clazpy)2(NCS)2], where M is Ni(II) or Zn(II). The synthesized complexes were characterized on the basis of elemental analysis, nuclear magnetic resonance, and infrared and electronic absorption spectroscopy.
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Why is it important?
The Clazpy compound and its complexes are significantly active against yeast and filamentous fungus with MIC and MFC values of 32 and 200 µg/ml, respectively. The Clazpy ligand showed higher antimicrobial activities against pathogenic yeast Cryptococcus neoformans (MIC/MFC 32/32 µg/ml) than both complexes (MIC/MFC 64/128 µg/ml). The [Ni(Clazpy)2(NCS)2] complex exhibited higher antimicrobial activities against fungal strains of Microsporum gypseum (MIC/MFC 64/128 µg/ml) than the [Zn(Clazpy)2 (NCS)2] complex.
Perspectives
These new azoimine metal complexes might therefore be considered as prospective antifungal agents.
Assoc. Prof. Dr. Luksamee Vittaya
Rajamangala University of Technology Srivijaya
Read the Original
This page is a summary of: Synthesis, characterization, and biological studies of novel Ni(II) and Zn(II) complexes with 5-chloro-2-(phenylazo)pyridine, ScienceAsia, January 2017, Science Society of Thailand - Mahidol University,
DOI: 10.2306/scienceasia1513-1874.2017.43.175.
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