INFLUENCE OF THE MENOPAUSAL STATUS TO THE FREQUENCY OF ENDOMETRIAL HYPERPLASIA AND CARCINOMA

What is it about?

The aim of this study was to determine the frequency and pathohistological features of endometrial hyperplasia and carcinoma in premenopausal and postmenopausal patients with abnormal uterine bleeding.

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Why is it important?

The frequency and pathohistological features of endometrial hyperplasia and carcinoma were investigated in 961 patients with AUB who underwent dilatation and curettage (D&C) between January and December 2006. Regarding the menopausal status, patients were divided into two groups: group of premenopausal patients (n=808) and group of postmenopausal patients (n=153). Endometrial hyperplasia was significantly (p<0,05) more frequent cause of AUB in premenopausal patients (23,4%) than in postmenopausal patients (13,7%). AUB caused by endometrial carcinoma was significantly (p<0,001) more common in postmenopausal patients (18,9%) than in premenopausal patients (1,4%). Compared to the postmenopausal patients, endometrial hyperplasia without atypia was significantly (p<0,01) more frequent while atypical hyperplasia was significantly (p<0,05) less frequent in premenopausal patients. In contrast to the premenopausal patients, endometrioid type and non-endometrioid type of endometrial carcinoma and carcinoma localized in endometrial polyp were significantly more common in postmenopausal patients (p<0,001, p<0,001, p<0,05, respectively)

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