Ion-pair Formation for the Determination of Mianserin Using Fast Sulphon Black F

What is it about?

Aim: The objective of the current study is to develop a colorimetric method for the determination of mianserin, an antidepressant drug. Materials and Methods: Fast Sulphon Black F, an acidic dye was used to develop a soluble colored ion-pair complex. The complex was extracted into an organic solvent and absorbance was measured. Results: Reaction conditions were optimized to obtain a sensitive and stable chromophore (λmax 554 nm) in dichloromethane. Good linearity was observed for the calibration curve plotted in the studied concentration range (4–14 μg/mL) with regression analysis (r > 0.9997). High percentage recovery values (98.25–101.40) show that the method is accurate. Reproducibility of the method is evident from lower relative standard deviation (<2%) for both intra- and inter-day precision studies. Conclusions: The proposed method is validated as per the existing ICH guidelines. This method is simple as it does not require any pre-treatment process.

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Why is it important?

The proposed method comprising FSBF as an ionpair forming agent is simple due to no requirement to maintain intricate reaction conditions (such as elaborate procedure for sample treatment and maintenance of critical optimum pH). Moreover, it is not necessary of using high-end costly instruments. These profits inspire the adaptation of this method in quality control divisions for mianserin routine analysis in tablet formulation as well as bulk drug.

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