What is it about?
Vaccination is routinly curently applicable in treatment and prevention of in infectious diseases. However, the cancer vaccination is a complex and encounters many obstacles. Currently, passive immunotherapy using monoclonal antibodies is an attractive approches, however vaccination of patients against cancer will protectthem long time and will produce memory to cancer. Thus the present work is about active immunization to Her2 one of well-known tumor associated antigens in mouse model.
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Why is it important?
Different Her2 extracellular recombinant proteins and full extracellular Her2 recombinant protein were applied to investigate their potentioal in tumore growth inhibition. Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses which seem to contribute to tumor growth inhibition in syngeneic mice.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. We need to optimize the anti- tumor responces in this strategy using removing barriers in generation protective immune responces to breastcancer.
Mahdi Shabani
Shahid Beheshti University of Medical Sciences
Read the Original
This page is a summary of: Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice, Immunotherapy, May 2018, Future Medicine,
DOI: 10.2217/imt-2017-0181.
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