What is it about?
Objective: The objective of the study was to develop a simple, validated, and affordable visible spectrophotometric method for determination of piperacillin (PIP) present in bulk and powder for injection formulation. Methods: In the present method, cobalt thiocyanate (CTC) was used as a chromogenic reagent where it forms 2:1 ion pair complex at pH 2 with PIP which is having secondary and tertiary amine groups.
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Why is it important?
Results: The formed bluish-green colored ion pair between PIP and CTC is quantitatively extractable into nitrobenzene with an absorption maximum of 665 nm. Regression analysis (r=0.9996) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (3–18 μg/mL). Low values of relative standard deviation (<2%) were observed indicating that the proposed method is reproducible, accurate, and precise.
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This page is a summary of: PIPERACILLIN ESTIMATION BY ION-ASSOCIATIVE COMPLEX FORMATION, Asian Journal of Pharmaceutical and Clinical Research, February 2019, Innovare Academic Sciences Pvt Ltd,
DOI: 10.22159/ajpcr.2019.v12i3.29289.
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