What is it about?
Findings of this study highlight the role of intestinal absorption in calcium stone formation: hypercalciuric stone formers have a more efficient calcium absorption in duodenum and jejunum compared to hypercalciuric subjects without kidney stones. This may lead to a higher calcium excretion peak in postprandial urine and an increased calcium salt precipitation risk. In conclusion high calcium absorption in duodenum and jejunum may expose hypercalciuric subjects to the risk of stones .
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Why is it important?
The main message of this study is that the composition of postprandial urine could be crucial for stone risk because an increased excretion of calcium, phosphate, oxalate and other lithogenic substances after a meal may activate the mechanism of stone production.
Perspectives
The study indicates a view which could change our diagnostic approach to stone disease.
Prof Giuseppe Vezzoli
Vita-Salute San Raffaele University
Read the Original
This page is a summary of: Intestinal Calcium Absorption among Hypercalciuric Patients with or without Calcium Kidney Stones, Clinical Journal of the American Society of Nephrology, June 2016, American Society of Nephrology,
DOI: 10.2215/cjn.10360915.
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