Immunosuppression versus Supportive Care on Kidney Outcomes in IgA Nephropathy in the Real-World Setting

What is it about?

Immunosuppression in management of IgA nephropathy remains controversial. The effect of immunosuppressive therapy on IgA nephropathy in unselected groups of patients in routine clinical practice needs further investigation. This large-scale cohort study used nationwide registry data from the China Renal Data System to compare the effectiveness of immunosuppression with that of supportive care. Use of immunosuppressive therapy was associated with a 40% lower risk of a composite kidney outcome including 40% decline of renal function from baseline and kidney failure. This real-world evidence suggest that immunosuppression may reduce the risk of clinical important kidney outcome in routine clinical practice.

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