Hyperthyroidism and Developmental Dysfunction

What is it about?

Thyroid hormones (THs) are essential for normal growth and development. Maternal hyperthyroidism degenerates the pyramidal and polymorphic cells was noted with loss of the axons or lateral dendrites of pyramidal cells. Maternal hyperthyroidism degenerates the stellate, basket, Purkinje, Golgi and granule cells of neonatal cerebellum. Maternal hyperthyroidism increases the growth of neonatal skeletal system. Thus, the administrations of L-T4 to mothers may cause several injurious anomalies in the development of their newborns and may lead to a pathophysiological state [6]. Age may represent a factor determining the severity and reversibility of the effects of hyperfunctioning of thyroid gland in the growth of various rat organs.

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Why is it important?

whether the adverse effects of maternal hyperthyroidism on fetal development are mediated directly by loss of the maternal hormones contribution to the fetus, indirectly by metabolic impairment of gestation, or both.