What is it about?
This chapter will first briefly describe the current and general aspects of tamoxifen and will then focus more in depth on various patented analogues, patented uses of tamoxifen, and patented combinations of tamoxifen with other antineoplastic drugs. We also discuss the biological effects of tamoxifen and its therapeutic targets.
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Why is it important?
This chapter provides an updated look at current tamoxifen-based therapies and new strategies for using tamoxifen to benefit cancer patients.
Perspectives
It is important to understand the mechanisms by which tamoxifen exerts antitumor activity in ER-negative tumours. This may lead to the synthesis of chemical structures that affect other potential cancer therapeutic targets while maintaining the effect on ERs. Producing new analogues of tamoxifen, similar to some of the compounds described in this chapter, could increase the specificity of anti-cancer drugs and reduce the side effects on healthy tissue to the benefit of cancer patients, including those with breast cancer and perhaps patients with a number of other malignancies as well.
Vázquez Sánchez Alma Yolanda
Universidad Tecnologica de Xicotepec de Juarez
Read the Original
This page is a summary of: New Tamoxifen-based Strategies in Cancer Research, October 2014, Bentham Science Publishers,
DOI: 10.2174/9781608059089114030018.
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