What is it about?
This article details the quality by design (QbD) concept for designing oral soluble films, the quality target product profile (QTPP), the critical material attributes for all ingredients in formulation, the critical process parameters during manufacturing these films, linking them to designing films with desired quality attributes.
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Why is it important?
This dosage form is biocompatible, biodegradable (depending upon polymer matrix selection), they have a potential for reduced side effects with improved safety and bioavailability (since they avoid first pass metabolism due to direct systemic absorption). The article summarizes all the research work and key patents on the subject.
Perspectives
Writing this article was a great pleasure as this subject is an emerging area of research for precision medicine. The manufacturing process is environment friendly (especially solvent casting) with less energy consumption during manufacturing, uses readily available pharmaceutical grade materials for formulation, is scalable to commercial scale and simplified process for smart dosage form design.
Suhani Sinha
GD Goenka Group
Read the Original
This page is a summary of: Oral Soluble Films: Attributes of the Polymeric Material and Critical Process Parameters for Designing Good Quality Films, Current Applied Polymer Science, December 2020, Bentham Science Publishers,
DOI: 10.2174/2452271603666191210121944.
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