What is it about?
The purpose of this study is to enhance oral solubility and bacterial cell permeability of the free base ciprofloxacin (CPX) using a single step CPX-chitosan (CT) self-assembly to form nanoplexes with organic counterions. It was envisioned that this would allow the delivery of larger amounts of active drug into the microorganisms.
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Why is it important?
Ciprofloxacin-free base is practically insoluble in an aqueous medium (0.0011 and 0.09 mg/mL at 25 and 37°C respectively). Its inorganic salt form (ciprofloxacin hydrochloride) is more soluble in water (1.35 mg/mL) however when administered orally, it exhibits decreased solubility in the stomach due to common ion effects.
Perspectives
In the study, Fractional Inhibitory Concentration (FIC) was less than 0.5 in both Gram-positive (0.031-0.250) and Gram-negative (0.036-0.281) microorganisms used, thus confirming synergistic enhancement of antimicrobial efficacy of CPX using CT. Thus, the design of drug-polymer nanocomplex formulation provides a platform for the synergistic enhancement of the therapeutic potency of antibiotics.
Dr Adekunle Sanyaolu
Read the Original
This page is a summary of: Chitosan-induced Synergy for Extended Antimicrobial Potency and Enhanced In Vitro Drug Release of Free Base Ciprofloxacin Nanoplexes, Pharmaceutical Nanotechnology, February 2020, Bentham Science Publishers,
DOI: 10.2174/2211738507666191021102256.
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