What is it about?

Squamous Cell Carcinoma (SCC) includes over 90% of malignancies in the oral cavity. Early diagnosis could effectively improve patients' quality of life and treatment outcomes of oral cancers. MicroRNAs as non-encoding genes have great potential to initiate or suppress cancer progression. Recent studies have shown that disruption of micro-RNA regulation is a common occurrence in cancers.

Featured Image

Why is it important?

Expression inhibition of onco-suppressor miRNAs, such as miR-15 and miR-16 may induce tumorigenesis. Regarding the role of miR-15 and miR-16 in carcinogenesis, the aim of our study is to investigate the expression of these two genes in the saliva of OSCC patients compared with the control group. Using these genes as a screening tool, their sensitivity and specificity in OSCC are also assessed.

Perspectives

The present study showed a decrease in the relative expression of miR-15a and miR-16-1 in OSCC patients compared with healthy individuals. It is probable to introduce salivary values of miR-15a and miR-16-1 as a non-invasive tool for early detection of OSCC. Decreased expression of miR-15a and miR-16-1 in OSCC shows the possible effective role of these genes in OSCC etiopathogenesis.

Maryam Koopaie
Tehran University of Medical Sciences

Read the Original

This page is a summary of: Assessment of MicroRNA-15a and MicroRNA-16-1 Salivary Level in Oral Squamous Cell Carcinoma Patients, MicroRNA, March 2021, Bentham Science Publishers,
DOI: 10.2174/2211536610666210506125036.
You can read the full text:

Read

Resources

Contributors

The following have contributed to this page