What is it about?
HPV16-miR-H1, HPV16-miR-H3, HPV16-miR-H5, HPV16-miR-H6, HPV-16 miR-1, HPV-16 miR-2, and HPV-16 miR-3 are transcribed in HPV-associated cancer lesions. Other high-risk HPV subtype genomes contain and may express additional miRNAs, that are just identified using bioinformatics.
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Why is it important?
The analysis of high-risk HPV genomes show the presence of subtype-specific pre-miRNA candidates.
Perspectives
The high-risk HPV miRNAs may have a role in carcinogenesis and may be targets for antagomiR therapeutic intervention
palmiro poltronieri
National Research council of Italy
Read the Original
This page is a summary of: State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development, MicroRNA, June 2018, Bentham Science Publishers,
DOI: 10.2174/2211536607666180328115155.
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