What is it about?
The red fluorescent dye Sulforhodamine 101 (SR101) has been used in neuroscience research as a useful tool for staining of astrocytes, since it has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this work is to label SR101 with positron emission radionuclides, in order to provide a radiotracer to study its biological behavior. This is the first attempt to label SR101 by [18F], using a chemical derivatization via a sulfonamidelinker and a commercially available platform. The derivatization of SR101 via sulfonamide-linker and the first radiosynthesis of [18 F]2B-SRF101 were performed. It was obtained in accordance with quality control specifications. In vitro stability studies verified that [18F]2B-SRF101 was suitable for preclinical evaluation
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Why is it important?
It could add a new tool for the diagnosis and follow up of neurodegenerative diseases.
Perspectives
Biological evaluation is being carried out, as well as dosimetry and toxicity studies. This will enable to assess its potential as a new tracer.
Eduardo Savio
CUDIM
Read the Original
This page is a summary of: Synthesis of [18F]2B-SRF101: A Sulfonamide Derivative of the Fluorescent Dye Sulforhodamine 101, Current Radiopharmaceuticals, November 2017, Bentham Science Publishers,
DOI: 10.2174/1874471010666170928112853.
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