What is it about?
Human/mouse chimeric models using iPSCs to study AD offer much promise in better replicating AD pathology and can be further exploited to elucidate disease pathogenesis with regards to the neuroinflammation hypothesis of AD.
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Why is it important?
Neurodegenerative diseases like Alzheimer’s Disease (AD) are a global health issue primarily in the elderly. Although AD has been investigated using primary cultures, animal models and post-mortem human brain tissues, there are currently no effective treatments.
Perspectives
Human/ mouse chimeric models using iPSCs can provide more information on the neuroinflammation hypothesis in AD
Mr Godwin Tong
University of Birmingham
Read the Original
This page is a summary of: Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer’s Disease: The Human Brain Outside the Dish, The Open Neurology Journal, September 2017, Bentham Science Publishers,
DOI: 10.2174/1874205x01711010027.
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