What is it about?
Glycogen synthase kinase-3β plays a significant role in the regulation of various pathological pathways relating to the Central Nervous System. By sequential application of in-silico tools, efforts have been attempted to design the novel GSK-3β inhibitors.
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Why is it important?
CADD has been introduced as a stand lone powerful tool in the drug discovery. we have identified novel, structurally diverse glycogen synthase kinase inhibitors.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.
seema kesar
Banasthali Vidyapith
Read the Original
This page is a summary of: In-Silico Screening of Ligand Based Pharmacophore, Database Mining and Molecular Docking on 2, 5-Diaminopyrimidines Azapurines as Potential Inhibitors of Glycogen Synthase Kinase-3β, Central Nervous System Agents in Medicinal Chemistry, July 2018, Bentham Science Publishers,
DOI: 10.2174/1871524918666180530074116.
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